Table 1 from Prophylactic mastectomy in high risk patients: a practice-based review of the indications. Do we follow guidelines? | Semantic Scholar (2024)

Factors that may influence choice of CPM included preoperative MRI, history of prior breast biopsies, immediate reconstruction, nipple preservation, family history, and BRCA status; those who chose CPM did not have improved survival.

awareness of prophylactic mastectomy is low among patients in this study and education about breast cancer and methods of prevention need to be improved.

A literature review was performed to identify studies that examined CPM decision making in women facing an early-stage breast cancer diagnosis with the aim of determining the most influential factors affecting her surgical choice.

The decision to pursue CRRM as part of treatment in women who have a low-to-moderate risk of developing a secondary cancer in the contralateral breast should consider both breast cancer individual-features and patients preferences, but should be not supported by the surgeon and avoided as first approach.

This is the only study to investigate the lived experience of TG for prophylaxis or palliation in individuals with and without genetic risk for stomach cancer, and the largest treatment impacts were learning to eat again and adjusting to the physical changes.

Treatment of mammary ptosis associated with augmentation mammoplasty demands a complex combination of techniques and careful preoperative analysis in order to define the best techniques to be used; this procedure lowers the need for surgical revisions and allows harmonious, stable, and long-lasting results.

The pros and cons of preventive mastectomy are analyzed, which suggest that prophylactic mastectomy is appropriate only for a small proportion of women who are at high risk for breast cancer.

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Twenty two percent of women at high risk for breast cancer presented at the time of pME with invasive carcinoma or intra-epithelial neoplasia undetected by imaging and clinical examination.

In women with a high risk of breast cancer on the basis of family history, prophylactic mastectomy can significantly reduce the incidence of Breast cancer.

The use of contralateral prophylactic mastectomy in the United States more than doubled within the recent 6-year period, and young patient age, non-Hispanic white race, lobular histology, and previous cancer diagnosis were associated with significantly higher rates.

Evaluating women's long-term satisfaction with CPM, factors influencing satisfaction, and psychological and social function after CPM concluded that each woman should weigh the benefits alongside the potential adverse effects.

The incidence of contralateral breast cancer seems to be reduced significantly aftercontralateral prophylactic mastectomy in women with a personal and family history of breast cancer.

While published observational studies demonstrated that BPM was effective in reducing both the incidence of, and death from, breast cancer, more rigorous prospective studies (ideally randomized trials) are needed.

Bilateral prophylactic mastectomy reduces the risk of breast cancer in women with BRCA1/2 mutations by approximately 90%.

Whether possible regret in the future is a rational reason for opting for prophylactic mastectomy, or whether it signifies an emotional coping process or strategy in which the future costs are no longer fully considered is discussed.

The Gail model significantly underestimates the risk of breast cancer in women with atypia, and its ability to discriminate women withAtypia into those who did and did not develop breast cancer is limited.

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